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Atique U. Ahmed currently appointed as Assistant Professor of Cancer Biology and member of the Lurie Comprehensive Cancer Center, Northwestern University, Chicago IL USA. He received his Ph.D. in Molecular Medicine from Mayo Graduate School, USA. He has over 60 publications that have been cited over 2500 times, and his/her publication H-index is 31 and has been American Cancer Society Scholar.


Glioma stem cells (GSCs), a rare population of cancer cells capable of self-renewal, are known to underlie therapeutic resistance in glioblastoma (GBM), the most common and aggressive adult primary brain tumor. Previously, we have shown that the anti-glioma chemotherapy temozolomide (TMZ) initiates remarkable plasticity in glioma cells and promotes the conversion of differentiated glioma cells to therapy resistant GSCs. Our initial investigation indicated that Polycomb group protein EZH2 is critical for this therapy-induced cellular plasticity. Genome-wide chromatin immunoprecipitation (ChIP) in parallel with DNA sequencing analysis (ChIP-seq) revealed 1449 distinct regions enriched for EZH2 binding, specifically at the promoter regions of several key genes including PTPRT, CDK5R2, and Siglec6. Gene expression microarray analysis showed that this binding decreased cognate gene expression in an effort to activate the master transcription factor STAT3, a key molecular factor in promoting the GSC niche. To further investigate this plasticity-based adaptation, we next performed histone 3 lysine 27 acetylation (H3K27ac) enrichment analysis in order to mark the transcriptionally active chromatin state on a genome wide scale before and after exposure to TMZ. A significant number of distal H3K27ac peaks were detected only after chemo- (n = 452) and radiotherapy (n= 1029), indicating that H3K27ac was modified by anti-glioma therapies in a locus-specific manner. Furthermore, a de novo motif analysis identified the homeobox TF binding motif (p=0.025) enriched within the H3K27ac peak surrounding sequences during therapy. By combining the transcriptome analysis from patientderived xenograft models and GBM patient data (TCGA) with the H3K27ac enriched marks, we have identified several novel homeobox transcription factors, which may contribute to therapyinduced cellular plasticity and adaptation response. These findings provide new insight into the molecular mechanisms by which epigenetic plasticity regulates the GSC niche and may improve our understanding of how GBM cells resist current treatment modalities.

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Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.


Registration fees do not include insurance of any kind.


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Cancellation Policy

If Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.


If Allied Academies postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

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All fully paid registrations are transferable to other persons from the same organization if registered person is unable to attend the event. Transfers must be made by the registered person in writing to . Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

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Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

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