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Helen He Zhu received her Bachelor Degree from Fudan University, China. She performed her Ph.D. study in Molecular Pathology at School of Medicine, University of California-San Diego and did her postdoctorate training in the Department of Biology , University of California-San Diego. In 2012, Dr. Zhu relocated back to China and started to work as an Associate Professor then Professor in Ren Ji Stem Cell Research Center, Ren Ji Hospital at School of Medicine, Shanghai Jiao Tong University. Her current work focuses on 1) adult tissue stem cells from hematopoietic system and prostate in tissue development and tumorigenesis. 2) roles of prostate cancer stem cells in therapeutic resistance and tumor metastasis. Her publication includes first author and corresponding author papers in Blood, PNAS, Gastroenterology, Clinical Cancer Research, Cancer Research and etc.


Castration resistant prostate cancer (CRPC) remains one of the most deadly and incurable cancer types worldwide. Tumor cells in CRPC patient samples display tremendous heterogeneity. Cancer stem cells (CSCs) are proposed to be the driving force in cancer progression and recurrence. Identification of the CSC or prostate cancer cell sub-population with greater castration resistance is a key to the development of targeted anti-CRPC treatment strategies. We report that the hTERThigh PCa cells exhibit CSC properties including stem cell associated gene expression signature, long term tumor propagating capacity, and epithelial-to-mensenchymal transition. hTERThigh CSC cells display distinct cell division modes and can undergo both symmetric division and asymmetric division, as compared to hTERT-/low Pca cells. Numb, an evolutionarily conserved cell fate determinant, tends to segregate into the more differentiating daughter cell during symmetric division and asymmetric division of hTERThigh CSC cells. Further investigation revealed that Numb is down-regulated and negatively correlated with PCa advancement. Functionally, Numb exerted an inhibitory role in xenograft prostate tumor growth and CRPC development via suppression of Notch and Hedgehog signaling. Through a Numb promoter based lentiviral reporter system, we were able to separate Numb-/low Pca cells from Numbhigh cells. Numb-/low PCa cells are smaller and quiescent, preferentially express Notch and Hedgehog downstream and stem-cell-associated genes, and are associated with greater resistance to androgen deprivation therapy. Targeting Notch and Hedgehog signaling with inhibitors can effectively deplete the Numb-/low castration resistant PCa cells. Collectively, these findings provide novel insight into cellular and molecular mechanisms for the development of advanced CRPC and to the development of effective anti-CRPC treatment strategies.

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Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.


Registration fees do not include insurance of any kind.


Please note that any (or) all transportation and parking is the responsibility of the registrant.


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For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrant's account.

All cancellations or modifications of registration must be made in writing to

Cancellation Policy

If Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.


If Allied Academies postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

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All fully paid registrations are transferable to other persons from the same organization if registered person is unable to attend the event. Transfers must be made by the registered person in writing to . Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

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Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

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Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies will advise the cancellation policy of your accommodation provider, prior to canceling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

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