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After obtaining a PhD degree in the University of Paris VII in 1993, Dominique Bonnet joined as a research fellow the group of Professor John Dick's laboratory in Toronto, Canada. In 1998, she accepted a position as Group Leader at the Coriell Institute for Medical Research, in New Jersey and became Assistant Professor, University of Medicine and Dentistry of New Jersey. In 2001, she moved to London at the Imperial Cancer Research Fund (ICRF; which became Cancer Research UK in 2002). In 2006, she became a Senior Group Leader at the London Research Institute (now part of the Francis Crick Institute). Since August 2002, she is also Professor at the University College of London, division of Biosciences, and a Senior Lecturer at the Institute of Child Health.
Dominique Bonnet is interested in understanding the regulation of the haematopoietic stem cells, both in normal development and during leukaemia. The laboratory is interested in studying both normal human haematopoietic stem cells (HSCs) and leukaemic stem cells (LSCs).